FORSTER • DECKER Amine synthesis

FORSTER - DECKER Amine Synthesis Selective monoalkylation of primary amines via imines An altemativa method is the reaction ol 1 and 2 in the preserve of NaCNBH4 or tnaceloxyborohydride (Borch reduction)/... 

Although Forster initially reported this reaction, it was Decker and Becker who investigated it in more depth and made this reaction an applicable route for the preparation of secondary amines. Therefore, this reaction is known as the Decker-Becker method or Forster reaction, but it is named the Decker-Becker secondary amine synthesis in this book. It is the synthesis of secondary amine by the condensation of primary amines with aldehydes to form an imine intermediate, which then reacts with alkyl halides via alkylation to Anally afford secondary amines after hydrolysis. This reacAon gives good results when methyl halides are used but works poorly and unstably when larger alkyl halides are applied. ... 

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