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Formylation of methionyl-tRNA

Formylation of methionylated tRNA " allows differentiation of the AUG start codon from internal AUG codons (14). MetRS aminoacylates tRNA" with methionine. A formyl group is linked covalently to the charged methionine via its amino moiety by the methionyl-tRNA formyltransferase enzyme, which uses N -formyl tetrahydrofolate as the formyl donor. This fMet-tRNA molecule binds directly to the P site of the ribosome to initiate protein synthesis, as compared with the A-site to which elongator tRNAs bind. [Pg.35]

Figure 29.21. Formylation of Methionyl-tRNA. Initiator tRNA (tRNAf) is first charged with methionine, and then a formyl group is transferred to the methionyl- tRNAf firomiV lo.formyltetrahydrofolate. Figure 29.21. Formylation of Methionyl-tRNA. Initiator tRNA (tRNAf) is first charged with methionine, and then a formyl group is transferred to the methionyl- tRNAf firomiV lo.formyltetrahydrofolate.
See other pages where Formylation of methionyl-tRNA is mentioned: [Pg.538]   
See also in sourсe #XX -- [ Pg.503 ]



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