Iron porphyrins formyl-substituted

M. Sono, A.M. Bracete, A.M. Huff, M. Ikeda-Saito, and J.H. Dawson, Evidence that a formyl-substituted iron porphyrin is the prosthetic group of myeloperoxidase magnetic circular dichroism similarity of the peroxidase to Spirographis heme-reconstituted myoglobin, Proc. Natl. Acad. Sci. USA 88 11148 (1991). 

Acetylation and formylation are classical reactions in porphyrin chemistry. H. Fischer s synthesis of hemin, for which he was awarded the 1930 Nobel prize, required treatment of deuterohemin (49) with acetic anhydride (or acetyl chloride) in the presence of tin(IV) chloride as a Friedel-Crafts catalyst the product, 3,8-diacetyldeuterohemin-IX (50), was obtained in high yield. Fischer also accomplished formylation of iron porphyrins using dichloromethyl methyl ether and a Friedel-Crafts catalyst (B-37MI30700). Both of Fischer s examples resulted in peripheral substitution of unsubstituted iron porphyrins. However,... 

Green Hemes Iron Chlorins and Iron Formyl-Substituted Porphyrins... 

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