4-Formyl-l-

Imidazole, 4-formyl-5-hydroxy-l-phenyl-mesoionic, 5, 372 Imidazole, 2-formyl-1-methyl-mass spectra, S, 360 Imidazole, 2-formyl-l,4,5-trimethyl-... 

Ethyl 10-chloro-7-methyl-6-oxo-l lb-phenyl-5,6,7,1 lb-tetrahydroisoxazolo[2, 3- /][l,4]benzodiazepine-l-carboxylate (563) gave a separable mixture of 6-chloro-4-(2-ethoxycarbonyl-2-formyl-l-phenylvinyl)-l-methyl-3,4-dihy-dro-2(17/)-quinoxalinone (564), 4-(2-benzoyl-2-ethoxycarbonylvinyl)-6-chloro-1-methyl-3,4-dihydro-2(l//)-quinoxalinone (565), and 6-chloro-l-methyl-3,4-dihydro-2(l//)-quinoxalinone (567) (EtOH, reflux, 21 h 2%, 8%, and 20%, respectively, after separation structures 564 and 565 were... 

Formyl-l-decalone, dianion, 48, 43 2-Formyl-6-methylcyclohexanone, dianion, 48, 41... 

Dimethylcyclohexanone and 2-benzyl-2-methylcyclohex-anone have been prepared similarly in yields of 60% and 55%, respectively.2 The procedure has been extended to the synthesis of 9-methyl-, 9-w-butyl-, and 9-benzyl-l-decalone from the dianion of 2-formyl-l-decalone in yields of 55%, 48%, and 58%, respectively.2... 

Various iodinated pyiToles have been prepared by direct iodination [19,24] or via thallation [25]. For example, 3-iodo-V-TIPS-pyrrole is prepared in 61% yield from 6 [19], and 3,4-diiodo-2-formyl-l-methylpyrrole is available in 54% yield via a bis-thallation reaction [25]. 

In addition to examining the vinylation of l-methyl-2-indolecarboxaldehyde with methyl acrylate (Pd(OAc>2/HOAc/AgOAc) to give methyl ( )-3-(2-formyl-l-methyl-3-indoiyl)-acrylate in 60% yield, Pindur found that similar reactions of methyl 3-(l-methyl-2-indolyl)-acrylate afford bis(carbomethoxy)carbazoles albeit in low yield [85]. Fujiwara discovered that the combination of catalytic Pd(OAc)2 with benzoquinone and t-butylhydroperoxide serves to couple indole with methyl acrylate to give methyl ( )-3-(3-indolyl)acrylate in 52% yield [86]. 

Adapting Gribble s method for synthesizing indol-3-yl triflate [37], Mdrour et al converted 2-formyl- l-(phenylsulfonyl)- l//-indole (31) to indol-2-yl triflate 32 in two steps. 32 was subsequently coupled with benzofuryl-2-boronic acid to furnish 2-benzofurylindole 33 [38, 39]. In another case, 2-bromoacetaniline was coupled with 2-formyl-3-furylboronic acid 35 [40]. The resulting Suzuki coupling adduct underwent a spontaneous cyclization, forming tricyclic furo[2,3-c]quinoline 36. 

Saito and Oki (109) tried to oxidize 9-(2-formyl-l-naphthyl)fluorene (68, X = H see Scheme 9) to find that, whereas the sp form reacted normally to... 

The synthesis of chiral pyrroloketopiperazines 174 was achieved via diastereo-selective Ugi reaction, with chiral 2-(2-formyl-l//-pyrrol-l-yl)acetic acids 175 conveniently derived from ot-amino acids [54]. The reaction proceeds with moderate diastereoselectivity trans. cis, up to 4 1) to give the target compounds 174 in good yields (Scheme 30). Noteworthy, the mixture of diastereomeres was separated by column chromatography and could be isolated as single diastereomeres. 

Mechanism of Action Reactivates cholinesterase activity by 2 formyl l methylpyri dinium ion. Therapeutic Effect Restores cholinesterase activity following organo-phosphate anticholinesterase poisoning. 

Kaiser, S.C. 1959. Metabolism of 2-formyl-l-methyl pyrldlnlum Iodide oxime (2-PAM). CWLR 2347. 

Chlor-3,3-diphenyl-2-formyl-l-methyl-2,3-dihydro-indol 35%... 

The phosphorylated esterases formed by the action of organophosphorus inhibitors are very stable, but some antidotes can reverse the inhibition. The oxime of 2-formyl-l-methylpyridinium ion (pralidoxime) is very effective.6 Its positive charge permits it to bind to the site normally occupied by the quartemary nitrogen of acetylcholine and to displace the dialkylphospho group ... 

Ojima and co-workers have also extensively studied the catalytic silylformylation of alkynes, employing a number of rhodium and rhodium-cobalt mixed metal complexes.122 The reaction of 1-hexyne with hydrosilanes under either ambient pressure or 10 atm of CO is catalyzed by a variety of metal complexes to yield (Z)-l-silyl-2-formyl-l-hexene, 1, and/or ( )-l-silyl-l-hexene, 2 [Eq. (48)].122a>c... 

The reactions of 1-alkynes with HSiMe2Ph catalyzed by Rh2Co2(CO)i2 proceed at 25 °C and ambient pressure of CO in toluene, yielding (Z)-2-formyl-l-silyl-l-alkenes... 

Amino-4-methylpyrimidine 2-Formyl-l-methyl-5-nitroimidazole Sulfuric acid... 

Into a mixture of 1.6 g of 2-amino-4-methylpyrimidine with 10 ml of glacial acetic acid is slowly added 2.13 g of concentrated sulfuric acid. A mixture of 2.4 g of 2-formyl-l-methyl-5-nitroimidazole in 20 ml of glacial acetic acid is slowly added to the mixture of the pyrimidine under stirring. The reaction... 

---