6-Formyl-2,3-dimethoxybenzoic acid

To a stirred mixture of 6-formyl-2,3-dimethoxybenzoic acid (1 1 mmol), secondary amine (2 1 mmol), and isocyanide 3(1 mmol) was added silica nanoparticles (0.2 g), and then the whole reaction mixture was stirred vigorously at room temperature for 7 h. After completion of the reaction, flash column chromatography (petroleum etherEtOAc = 5 2) of the residue furnished purified desired product 4. All the products were characterized by their elemental analyses and spectral studies. 

Formyl-2,3-dimethoxybenzoic acid Opianic acid CioFliot s 619-06-1 210.183 nd (w) 160 s FtOH, eth... 

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