Formulated SEFA

To conclude this section, previous reports on the beneficial effects of topically applied moisturizing preparations have often focused on optimizing their physiological lipid composition. The results found for the formulated SEFA and petrolatum in this work, when viewed relative to the neat materials, suggest that proper formulation of even nonphysiological moisturizing agents will enhance the beneficial effect these materials have on outer SC lipid structure. 

FIGURE 28.8 (a) Formulated (2%) SEFA site from a 42-year-old male. The characteristic SEFA look. (b) Formulated (10%) SEFA site. In addition to the SEFA look, an extra Landmann unit is present within the amorphous material. This extra Landmann unit is slightly separated from the peripheral lamella, which is common. Bar = 100 nm. 

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