Formic acid quantitative estimation

Their main results may be summarized as follows. The periodic acid oxidation of polyols afforded a method for quantitative determination of these compounds, and it was demonstrated that the first reaction products are carbonyl compounds, themselves in turn degraded from their reducing end. After complete oxidation, it is possible to make an estimate of the consumption of oxidant, as well as of the formic acid and formaldehyde that are produced. The monosaccharides are attacked preferentially at the neigh-... 

Eikmann T, Prajsnar D, Einbrodt HJ. 1987. Quantitative estimation of formaldehyd exposure in normal population collectives on the basis of the formic acid excretion in urine [Abstract]. Zentralbl Bakteriol Mikrobiol Hyg [B] 183 483-484. 

The solvent may also drastically affect the anchimerically assisted fraction in nucleophilically assisted ionization reactions. As the solvent becomes more nucleophilic, there is greater solvent participation, if possible, at the expense of neighboring group assistance. The data in Table 4 are illustrative of this effect. It is obvious that in both formic acid and acetic acid there is considerable MeO-5 and MeO-6 nucleophilic participation. In ethanol, however, the ratio kjk is diminished as solvent attack (fcj becomes more effective. These effects may be quantitatively assessed. Winstein et alP used a Taft treatment for the system RCH2OBS in estimating the kj portion of the solvolytic rate constant [Eq. (14)]. Values for K/K where /c, is the titrimetrically observed rate constant, were determined. 

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