Formation of Eight-Membered and Larger Carbocycles

The intramolecular Mizoroki-Heck reaction also allows for the synthesis of medium-sized and even large rings the latter were usually synthesized under high dilution conditions or on a solid support (Chapter 14). 

(2002) The intramolecular Heck reaction, in Organic Reactions, Vol. 60 (ed. L.E. Overman), John Wiley Sons Inc., New York, pp. 157-534. 

and Ban, Y. (1977) The reactions and syntheses with organometallic compounds. V. A new synthesis of indoles and isoquinolines by intramolecular palladium-catalyzed reactions of aryl halides with olefinic bonds. Tetrahedron Lett., 1037-40. 

Baldwin, J.E. (1976) Rules for ring closure. J. Chem. Soc., Chem. Commun., 734-6. 

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