Formation, Activation, and Aggregation of Platelets B

Platelets are fragments of multicellular megakaryocytes. They constitute the smallest formed elements of blood (diameter 1-4 pm) and, devoid of a cell nucleus, are no longer capable of protein synthesis. Platelets can be activated by various stimuli, leading to  

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The propensity of platelets to aggregate can be inhibited by various pharmacological interventions. 

1-mediated synthesis of thromboxane. Low daily doses (75-100 mg) may be suf cient. Indications include prophylaxis of re-infarc-tion after myocardial infarction and of stroke. Despite the low dosage, adverse effects such as gastric mucosal damage or provocation of asthma attacks cannot be ruled out. 

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