Formaldehyde Hexetidine

Nitro alcohols react with amines to form nitro amines. Such a reaction can be carried out with a wide variety of primary and secondary amines, both ahphatic and aromatic a basic catalyst is requited if aromatic amines are involved. The products of reactions between dihydric nitro alcohols and amines are nitrodiamines, many of which are good fungicides (qv). Dihydric nitro alcohols, primary amines, and formaldehyde react to yield nitrohexahydropyrimidines (4). Nitrohexahydropyrimidines can be reduced to the corresponding amines, some of which are good fungicides or bactericides, eg, hexetidine [141-94-6] (5-amino-l,3—bis(2-ethylhexyl)-5-methylhexahydropyrimidine). 

Fluoro uracil mercury Tegafur Formaldehyde Biperiden Bronopol Cortivazol Edetate disodium Glaziovine Hexetidine Meptazinol Metampicillin sodium Methylol riboflavin Nifurfoline Nifurtoinol Noxytiolin Oxymetazoline HCI Phenindamine tartrate Pipebuzone Thihexinol Timonacic sodium Triclobisonium chloride T romethamine Tyloxapol Formamide Cimetide Primidone Protriptyline Razo xane Spiperone Formic acid Bupivacaine... 

From the spectrum of effectiveness one can conclude that the activity of Hexetidine is not the result of released formaldehyde. This is in line with the fact that the formaldehyde contained in Hexetidine is not traceable with the Tannenbaum method or other more severe methods, although the synthesis pathway for Hexetidine... 

DMDM hydantoin, dodecylguanidine acetate, ethyl benzoate, ethylparaben, formaldehyde, formic acid, hexachlorophene, hexetidine, hexamidine isethionate, isopropyl sorbate,... 

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