Form, Pharmacokinetics, and Disposition Data

TABLE I. Dosage form, pharmacokinetics, and disposition data... 

Even though the absorption rate constant (kf) defines the rate of absorption, its accurate determination is largely dependent on the adequacy of the plasma concentration-time data associated with the absorption phase of the drug. When a drug is administered orally, as a conventional (immediate-release) dosage form, or injected intramuscularly as an aqueous parenteral solution, the absorption and disposition kinetics can often be analysed in terms of a one-compartment pharmacokinetic model with apparent first-order absorption. The plasma concentration-time curve is described by the equation... 

---