Foodstuffs aromatic amines

Specific requirements for the end products include tests and migration limits for various types of toxic or harmful compounds such as Michler s ketone (4,4 bis(dimethylamino)benzophenone), 4,4 bis(diethylamino) benzophenone (DEAB), diisopropyhiaphthalenes (DIPNs) phthalates, solvents, partially hydrogenated terphenyls (HTTP), azo colourants, fluorescent whitening agents, primary aromatic amines, polycyclic aromatic hydrocarbons (PAH) and benzophenone. The amounts of these substances should be either below the detection limits or, in some cases (DIPN, HTTP, solvents) as low as can be reasonably achieved. For benzophenone a specific migration limit of 0.1 mg/dm is defined. The requirements generally apply to products intended to be used in contact with aqueous and/or fatty foodstuffs or also with dry, non-fatty foodstuffs (requirements for DIPNs, HTTP, phthalates and solvents). 

The presence of PAA may serve as fingerprints for detection of other functional groups. Unreacted isocyanates used in manufacture of corks may migrate to foodstuffs and hydrolyze there to the corresponding PAA. Thus, cork homogenates in water were extracted with hexane and analyzed by GC-MS for the presence of diamines such as 2,4-diaminotoluene (2e), 2,6-diaminotoluene (2f) and 4,4 -methylenedianiline (5a)65. A combination of pyrolysis with GC-MS was applied to qualitative analysis of azo dyes by detection of aromatic amines in the pyrolysate. This fast detection method was applied in... 

Because of their carcinogenicity, amines have to be monitored. For example, primary aromatic amines (PAAs) are substances that can be transferred from food packaging materials into foodstuffs. In the production of multilayer plastic materials it is common to use reactive adhesive mixtures containing aromatic isocyanate monomers. In cases of incomplete curing, residues of the aromatic isocyanates react with water to produce PAAs. Some of these amines, including... 

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