Follicle stimulating hormone function

Menopause is the permanent cessation of menses owing to a loss of ovarian follicular function. The diagnosis of menopause is primarily a clinical one and is made after a women experiences amenorrhea for 12 consecutive months. The loss of ovarian follicular activity leads to an increase in follicle-stimulating hormone (FSH), which, on laboratory examination, may help to confirm the diagnosis. 

Ulloa-Aguirre, A., Timossi, C., Damian-Matsumura, P., and Dias, J.A. 1999. Role of glycosylation in function of follicle stimulating hormone. Endocrine 11(3), 205-215. 

Follicle stimulating hormone is responsible for the growth of testes. It promotes spermatogenesis. Along with LH, FSH plays an essential role in maintaining the normal testicular functions such as development of male sex organs e.g. penis, scrotum development of secondary sexual characters e.g. growth of facial. 

The Sertoli cells in the testes appear to be the main target of the testicular toxicity. Proposed mechanistic h otheses relate to reduced testicular zinc levels, altered hormonal status, altered metabolic function and altered follicle-stimulating hormone reactivity. 

Combined cytostatic drug therapy for Hodgkin s disease in childhood often results in abnormal endocrine function, particularly increases in follicle-stimulating hormone, prolactin, and thyroid-stimulating hormone (318). 

The pharmacokinetics of morphine have been studied,201-203 as has its receptor binding,204-206 and its effects on hypothermia,207 on calcium uptake by synaptosomes208 and lysed synaptosomes,209 on metabolism of catecholamine in brain,210 on levels of corticosteroids and growth hormone in plasma,211 on leuteinising hormone,212 follicle-stimulating hormone,212 and prolactin,212-215 on neuroendocrine function,216 on brain function and biochemistry,217-226 on behaviour,227-240 on the gastrointestinal tract241 and on the cardiovascular... 

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