Folic acid brain function

The proper functioning of the mind is known to require the presence in the brain of molecules of many different substances. For example, mental disease, usually associated with physical disease, results from a low concentration in the brain of any one of tbe following vitamins thiamine (Bi), nicotinic acid or nicotinamide (Bs), pyridoxine (Be), cyanocobalamin (Bu), biotin (H), ascorbic acid (C), and folic acid. There is evidence that mental function and behavior are also affected by changes in the concentration in the brain of any of a number of other substances that are normally present, such as L(-l-)-glutamic acid, uric acid, and y-aminobutyric acid S). 

The primary function of B vitamins is to help body cells produce energy through metabolism of carbohydrate, fat and protein. These vitamins are required for brain energy metabolism, neurotransmitter synthesis and functioning, and myelination of the spinal cord and brain cells. More specifically, folic acid, vitamin Bg and Bj2 deficiencies or congenital defects in enzymes that are involved in the metabolism of these B vitamins, are known to be associated with impaired brain function (Rosenberg 2001). Folic acid, vitamin Bg and B2 are also involved in homocysteine metabolism known to be important for cardiovascular function. 

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