Folding transition

DA d Avignon, GL Bretthorst, ME Holtzer, A Holtzer. Thermodynamics and kinetics of a folded-folded transition at vahne-9 of a GCN4-hke leucine zipper. Biophys I 76 2752-2759, 1999. 

These results are plausible since according to Sand a two-fold concentration of a component yields a four-fold transition time. Now, these features show, in contrast to the net separation and pure additivity of polarographic waves and their diffusion-limited currents as concentration functions, that in chrono-potentiometry the transition times of components in mixtures are considerably increased by the preceding transition times of any other more reactive component, which complicates considerably the concentration evaluation of chronopotentiograms. 

O Toole, E.M., Panagiotopoulos, A.Z. Monte Carlo simulation of folding transitions of simple model proteins using a chain growth algorithm. J. Chem. Phys. 1992, 97, 8644-52. 

Table 8.1 Effect of salt and temperature on the folding transition of DNA...

It is noted that both the effects of salt and temperature are opposite to those of multivalent cations (Table 8.1). This opposition is explained by taking into account the effect on the enhanced uptake of counter ions accompanied by the folding transition (see Figure 8.4). 

CROSS-TALK BETWEEN FOLDING TRANSITION AND HELIX-COIL... 

A recent study has shown that two different kinds of conformational changes, helix-coil transition and the folding transition, mutually interfere with each other in a drastic manner (Mikhailenko et al., 2000). As the melting of the double stranded structure, or helix-coil transition, is an essential process in the genetic activity, further studies on the biological role of the conformational change of DNA are awaited. 

Mayama, H., Iwataki, T. and Yoshikawa, K. (2000) Thermodynamics in the folding transition of single T4 DNA molecules in poly(ethylene glycol) solution. Chem. Phys. Lett., 318, 113-117. 

Yamasaki, Y., Teramoto, Y. and Yoshikawa, K. (2001) Disappearance of the negative charge in giant DNA with a folding transition. BiophysJ., 80, 2823-2832. 

Yoshikawa, K., Noguchi, H. and Yoshikawa, Y. (1997a) Folding transition in single long duplex DNA chain. Progr. Colloid. Polym. Sci., 106, 204-208. 

---