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Fold recognition algorithms

Detecting low-homology models (using fold-recognition algorithms)... [Pg.106]

PTPS (6-Pyruvoyl Tetmhydropterin Synthase). 6-Pyruvoyl tetrahy-dropterin synthase catalyzes formation of tetrahydrobiopterin biosynthesis. Tetrahydrobiopterin is a cofactor for several important enzymes, such as aromatic amino acid hydroxylases and nitric oxide synthase (57). H. pylori protein HPAG1 0913 shares homology with members of the protein domain family PTPS. H. pylori protein shares poor sequence identity of 14% with the PTPS profile at an E-value of 10 10 and covers about 95% of the length of the profile. Fold recognition results also confirm the relationship between H. pylori protein and the PTPS protein domain family. A fold recognition algorithm ensures fitness of the H. pylori protein sequence on the three-dimensional structure of PTPS from... [Pg.167]

Firth, J. Li, C. W. Murray. Protein fold recognition by threading comparison of algorithms and analysis of results. Prot. Eng. 1995, 8, 1197-1204. [Pg.234]

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See also in sourсe #XX -- [ Pg.106 ]



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