Fmoc-D-Ser

Fmoc-amino acids used as building blocks of testing compounds are as follows Fmoc-Asp(OtBu)-OH, Fmoc-Cys(Trt)-OH, Fmoc-Asn(Trt)-OH, Fmoc-Gln(Trt)-OH, Fmoc-Met-OH, Fmoc-Glu(OtBu)-OH, Fmoc-Lys (Boc)-OH, Fmoc-Ile-OH, Fmoc-His(Trt)-OH, Fmoc-Tyr(tBu)-OH, Fmoc-Arg(Pmc)-OH, Fmoc-Phe-OH, Fmoc-Ser(tBu)-OH, Fmoc-Thr(tBu)-OH, Fmoc-Val-OH, Fmoc-Pro-OH, Fmoc-Trp(Boc)-OH, Fmoc-D-Ala-OH, Fmoc-D-Arg(Pmc)-OH, Fmoc-D-Trp(Boc)-OH, Fmoc-D-Cys(Trt)-OH, Fmoc-D-Asp(OtBu)-OH, Fmoc-D-Glu(OtBu)-OH, Fmoc-D-His(Trt)-OH, Fmoc-D-Gln(Trt)-OH, Fmoc-D-Leu-OH, Fmoc-D-Met-OH, Fmoc-D-Pro-OH, Fmoc-D-Ser(tBu)-OH, Fmoc-D-Lys(Boc)-OH, Fmoc-D-Tyr(tBu)-OH, Fmoc-D-Thr(tBu)-OH, Fmoc-D-Phe-OH, Fmoc-D-Asn(Trt)-OH, Fmoc-3-(4-pyridyl)alanine, Fmoc-D-3-(3-pyridyl)alanine, Fmoc-4-tert-butoxyproline, Fmoc-3-chlorophenylalanine, Fmoc-norleucine, Fmoc-2-cyclohexylglycine, Fmoc-2-aminoisobutyric acid, Fmoc-tranexamic acid, Fmoc-(i ,S)-3-amino-3-(2-furyl)propionic acid, Fmoc-(i ,S)-(6,7-di-methoxy)-l,2,3,4-tetrahydroquinoline-3-carboxylic acid, Fmoc- (R, S)-3-amino-3-(4-hydroxyphenyl)propionic acid, Fmoc-(i ,S)-3-aminovaleric acid, Fmoc-(i ,5 )-3-amino-3-(3,4-dichlorophenyl)propionic acid, Fmoc-isonipecotic acid, Fmoc-(i ,S)-3-amino-3-(3,4-methylenedioxyphenyl)... 

Hydroxybenzotriasole Boc-Arg(HCI)-OH Diisopropylcarbodiimide Fmoc-D-Ser(But)-OH Fmoc-Tyr(BrZ)-OH Fmoc-His(Fmoc)-OFI Pyr-OH (pyroglutamic acid) Boc-Pro-OBzi-polystyrene resin 1% cross-linked with divinylbenzene... 

In Ref. 42 a similar approach was chosen as in Ref. 39 using stereoisomers of the type Fmoc-L-Asp-L-Asp-D-Xaa-D-Xaa (Xaa = Gly, Ala, Phe, His, Ser, Tyr). Interestingly, in part the findings are different. The ACE/MS hyphenation caused a number of practical problems affecting the reliability of the system. Surprisingly, the authors faced problems with positive ESI and were forced to use negative ionization. Because of the use of the nonvolatile Tris buffer, crystallization problems occurred frequently. Only high-EOF conditions prevented this knockout scenario. However, the description of problems and related solutions is very instructive. 

A"-Fmoc-Ser 0-[3,4,6-tri-0-benzyl-2-0-(2,3,4,6-tetra-0-benzyl-a-D-mannopyranosyl)-a-maimopyr-anosyl])-OBzl (15, R1 = H) 250 ... 

JV -Fmoc-Ser-(3,4,6-tri-0-acetyl-2-deoxy-2-iodo-a-D-mannopyranosyl)-OBzl (27) 13 ... 

---