Indometacin Flurbiprofen

Diclofenac can cause reduced comeal sensitivity, starting from 15 minutes after instillation and measurable after 1 hour (3). This corneal hypesthesia can be useful in reducing pain and discomfort in ocular inflammation and after surgery. In chronic treatment, however, the effect of diclofenac on corneal nerves can cause either increased healing time of the corneal epithelium or a neurotrophic epitheliopathy in patients with conditions that predispose to epithelial damage, such as dry eyes. In contrast, flurbiprofen, indometacin, and ketorolac tro-methamine did not cause corneal hypesthesia. 

Huskisson EC, Woolf DL, Boyle DV, Scott J. A trial of naproxen, flurbiprofen, indometacin and placebo in the treatment of osteoarthritis. Eur J Rheumatol Inflamm 1980 2 69. 

NS AIDs METHOTREXATE t methotrexate levels, with reports of toxicity, with ibuprofen, indometacin and possibly diclofenac, flurbiprofen, ketopro-fen, meloxicam and naproxen Uncertain postulated that an NSAID-induced i in renal perfusion may have an effect Consider using an alternative NSAID... 

Nervous system effects with flurbiprofen are less common than with indometacin (3). Flurbiprofen precipitates extrapyramidal reactions, albeit rarely (SEDA-15, 101), and a parkinsonian syndrome has been reported in a predisposed patient (SEDA-15, 101). 

The concurrent use of two or more NSAIDs increases the risk of gastrointestinai damage. Diflunisal raises serum indometacin levels about twofold but does not affect naproxen levels. The concurrent use of indometacin and flurbiprofen does not appear to affect the pharmacokinetics of either drug. Floctafenine does not alter diclofenac levels. Indometacin caused renal impairment in a patient recovering from phenylbutazone-induced acute renal failure. 

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