Flurazepam aldehyde

Flurazepam (Dal mane ) 8 10-30 15-30 Oxidation N-dealkylation Hydroxyethylflurazepam Flurazepam aldehyde N-DAF High risk of hangover and residual effects... 

Flurazepam (Dalmane) 1 8 15-30 Oxidation /V-dealkylation Hydroxyethylflurazepam, flurazepam aldehyde A/-desa Iky If 1 u razepa mc... 

The disposition of flurazepam (IV) was examined in a dog and man. The compound was metabolized by successive N-dealkylation to yield, ultimately, the alkylamine, whi was excreted in the urine. Man oxidatively deaminated the alkylamine to a conjugate of the homologous alcohol, whereas the dog formed the corresponding carboxylic acid, both presumably via an aldehyde intermediate. A metabolite also found in the urine of both species was the fluorinated analogue of oxazepam, although this metabolite is probably formed by a pathway in which N-dealkylation precedes 3-hydroxylation, since the 3-hydroxy derivative of flurazepam was not detected in urine. 

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