Fluoroquinolones classification

Volpe DA (2004) Permeability classification of representative fluoroquinolones by a cell culture method. AAPS PharmSci 6(2) article 13. 

Antibiotics can be classified according to their effects on the biochemistry or molecular biology of pathogens. There are ribosomal inhibitors (macrolides), cell wall disrupters 0-lactams), DNA disturbers (fluoroquinolones), and metabolic poisons (trimethoprim-sulfamethoxazole). Antibiotics also can be classified according to whether they are static (inhibitory) or cidal (lethal). The classification of drugs as either static or cidal is based on laboratory assessment of the interaction of pathogen and antibiotic drug. 

The classification of the fluoroquinolones into generations is somewhat informal and unstandardized. However, it does serve a clinical purpose by helping to classify them on the basis of their spectra of action and indications (Table 11-9). 

Bryskier A, Chantot JF. Classification and structure-activity relationships of fluoroquinolones. Drugs 1995 49(Suppl 2) 16-28. 

Volpe DA. Permeability Classification of Representative Fluoroquinolones by a Cell Culture Method. AAPSPharm Set 2004 6,Article 13. 

A. Classification and Pharmacokinetics The original fluoroquinolone is norfloxacin others in the group include ciprofloxacin, ofloxacin, levofloxadn, lomefloxacin, and sparfloxadn. 

Bryskier, A. and Chantot, J.F., Classification and structure-activity relationship of fluoroquinolones. Drugs, 49(Suppl. 2), 16, 1995. 

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