4-Fluorobenzenesulfonyl chloride

QH5F 462-06-6) see Bromperidol Flubendazole Haloperidol Suprofen 4-fluorobenzenesulfonyl chloride (CftH4ClF02S 349-88-2) see Ramatroban 4-fluorobenzonitrile... 

To a solution of D-valine (54.6 mmol) dissolved in 62 ml water and 25 ml acetone was added triethylamine (117 mmol). The solution was cooled to 0°C and 4-fluorobenzenesulfonyl chloride (51.4 mmol) dissolved in 25 ml acetone added dropwise. After stirring at ambient temperature 20 hours, the solution was concentrated, the aqueous residue extracted twice with 50 ml toluene and then acidified with HCl to pH 1. The solution was extracted 3 times with 50 ml EtOAc, washed successively with 50 ml apiece of KHSO4, water, and brine, dried, concentrated, and triturated with hexane. The product was isolated in 89% yield. MS and elemental analysis data supplied. 

Fluorobenzenesulfonyl chloride 2-Fluorobenzoicacid 3-Fluorobenzoicacid 4-Fluorobenzoic acid 2-Fluorobenzonitrile 4-Fluorobenzonitrile 2-Fluorobenzoyl chloride... 

Fluorobenzaldehyde 4-Fluorobenzaldehyde Fluorobenzene 4-Fluorobenzeneaceticacid 2-Fluorobenzeneacetonitrile 4-Fluorobenzeneacetonitrile 4-Fluorobenzenemeihanamine 4-Fluorobenzenemelhanol 4-Fluorobenzenesulfonyl chloride 2-Fluorobenzoicacid... 

Prepared by reducing p-fluorobenzenesulfonyl chloride with HI (60% yield). 

Some compounds gave abnormal results thus fluorobenzene with neat chlorosulfonic acid (40 C) only gave 4,4 -difluorodiphenyl sulfone. On the other hand, treatment of fluorobenzene with the reagent in chloroform solution afforded some /7-fluorobenzenesulfonyl chloride while m-difluorobenzene reacted with excess reagent (30-40 C, 3 hours) to give 2,4-difluorobenzenesulfonyl chloride (98.6% yield). ... 

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