Fluorine in Drug Designs

These factors are operative singly or sometimes cooperatively to affect the pharmacological properties of the fluorinated molecules. The following examples explain the pharmacological action mechanism of the fluorinated molecules in an organism on the basis of the factors discussed in detail in Chapters 1-4. 

---

The special advantages of selective substitution of fluorine in drug design and development are well recognized and have been reviewed extensively [21]. Small size and high electronegativity impart special properties to fluorinated... 

K.L. Kirk, Selective fluorination in drug design and development, an overview of biochemical rationales, Curr. Top. Med. Chem. 6 (2006) 1447-1456. 

It should be clear from this cursory discussion, and the publications referred to, that the roles of fluorine in drug design and in applications to biochemistry are very large and burgeoning topics that are hugely important. 

Uneyama, K. Fluorine in drug designs. Organofluorine Chemistry, Blackwell Publishing Oxford, UK, 2006. 

Given the importance of fluorination in drug design, chiral A/-fluoro reagents were also sought after and developed. The first such reagents to be developed were the V-fluorocamphorsultams (a sultam is a cyclic sulfonamide) ... 

Tactical Applications of Fluorine in Drug Design and Development... 

---