Fluorination, of quinoxalines

Indirect fluorination of quinoxaline gave a separable mixture of 2-fluoro- and 2,3-difluoroquinoxaline (I2, Et3N, CIP2CCP2CI, P2 -f N2i, 5°C, min 48%... 

Excluding pyrimidine derivatives electrophilic fluorination of other diazines was almost not studied. To the best of our knowledge there is no examples of electrophilic fluorination of pyridazines and only 1 paper and 1 patent devoted to fluorination of pyrazines and quinoxaline. Chambers and co-workers described fluorination of quinoxalines 29 in good yields using elemental fluorine-iodine mixtures at room temperature (Scheme 8). Mono- (30) and difluorinated products 31 were formed in different ratio depending on amount of fluorine used in the reaction. It should be noted that pyrazine, pyrimidine and pyridazine were recovered unchanged using similar condition [42]. 

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See also in sourсe #XX -- [ ]

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