Fluorination of a Carboxylic Acid with Sulfur Tetrafluoride

Fluorination of a Carboxylic Acid with Sulfur Tetrafluoride 

Sulfur tetrafluoride is a hazardous and highly toxic gas [4], in some aspects comparable with phosgene [12]. For reactions with SF4 with or without HF autoclaves made from Hastelloy C with Monel 400 piping and valves are recommended [13]. When handling SF4 sufficient ventilation must be provided and protective goggles and gloves should be worn. On autoclave depressurization, excess SF4 and HF should be scrubbed with potassium hydroxide solution. 

Generation of a Trifluoromethoxy Croup by Oxidative Fluorodesulfuration of a Xanthogenate 

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