Fluocortin butyl ester

P. S. Burge, J. Efthimiou, M. Tumer-Warwick, and P. T. Nelmes, Double-bhnd trials of inhaled beclomethasone diproprionate and fluocortin butyl ester in allergen-induced immediate and late asthmatic reactions, Clin. Allergy 72 523 (1982). 

CN (6a,l lp,16a)-6-fluoro-l l-hydroxy-16-methyl-3,20-dioxopregna-l,4-dien-21-oic acid butyl ester fluocortin... 

There are also several compounds with more atypical substitution for instance, fluocortine in which the 2O-CH2OH is replaced by a butyl ester group (Figure 8.39), fluticasone in which the 17-CO—CH2OH is replaced by a a-fluoromethylthioester... 

Fig. 15.13) is an anti-inflammatory steroid obtained in one of the early approaches aimed at integrating ester moieties into steroid structures. Metabolism studies on fluo-cortolone revealed a number of oxidative and reductive metabolites in human urine (124), including fluocortolone-21-acid, an inactive metabolite. Synthesis and pharmacological evaluation of its different ester derivatives yielded fluocortin butyl (30, Vaspit, Novo-derm, Varlane), the butyl ester of a C-21 car-boxy steroid (125-128). The ester is an antiinflammatory agent of rather weak activity, and any portion absorbed systemically follow-ingtopical application is hydrolyzed into inactive species. 

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