Fluconazole intravenous dosage

The safety profile of fluconazole has been assessed in 562 children (aged 0-17 years 323 boys and 239 girls), enrolled into 12 clinical studies of prophylactic or therapeutic fluconazole in predominantly immunocompromised patients (66). Most of the children received multiple doses of fluconazole 1-12 mg/kg, given as oral suspension or intravenously. Overall, 58 children reported 80 treatment-related adverse effects. The most common adverse effects were associated with the gastrointestinal tract (7.7%), the skin (1.2%), or the liver and biliary system (0.5% or three patients). Overall, 18 patients discontinued treatment owing to adverse effects, mainly gastrointestinal. Dosage and age did not affect the incidence and pattern of adverse effects. Treatment-related... 

Fluconazole (diflucan, others) is marketed as tablets for oral administration, powder for oral suspension, and intravenous solutions containing 2 mg/mL. Dosage is 50-800 mg once daily for oral or intravenous administration. Children are treated with 3—6 mgAg once daily. 

The interaction between tacrolimus and fluconazole is established, clinically important and can develop rapidly (within 3 days). The authors of one of the reports say that up to 200 mg of oral fluconazole daily can be used safely and effectively provided that the tacrolimus dosage is reduced by half One study specifically examining dose adjustments suggests that fluconazole can be safely used if 60% of the original tacrolimus dose is given. If tacrolimus is given intravenously, no clinically important interaction appears to occur. ... 

The management of a pharmacokinetic interaction of voriconazole with everolimus has been described in a 65-year-old man who underwent orthotopic liver transplantation complicated by intestinal perforation, sepsis, and acute renal insufficiency [32 ]. He received intravenous fluconazole 400 mg followed by 100 mg/day and oral everolimus 0.75 mg bd the steady-state Cmin of everolimus was satisfactory. On day 72 after transplantation, because of invasive aspergillosis, antifungal therapy was switched to intravenous voriconazole 400 mg bd on the first day followed by 200 mg bd to prevent drug toxicity the dosage of... 

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