Flow reador

A Cu-Box complex supported on monolith (51) was developed for the enantio-selective cydopropanation of ethyl diazoacetate. The flow reactions using (51) provided an increase in enantioselectivities of about 20% relative to those for the homogenous batch process (Scheme 7.38) [142]. Pyridine-oxazolidine based monoliths (52) and (53), whose central metals were Ru and Cu, respectively, were also developed [143,144]. Mesoporous silica was utilized as a support for the Cu-Box complex for asymmetric cydopropanation in a flow reador. Aza(bisoxazoline) was easily immobilized on siliceous mesocellular foam MCF) microparticles, which are... 

Wu, C. and Zeng, T. (2007) Size-tunable synthesis of metallic nanopartides in a continuous and steady-flow reador. Chemistry of Materials, 19,123-5. 

GlaxoSmithKline Pharmaceuticals in Harlow, UK, performed the Hantzsch synthesis of 2-bromo-4 -methylacetophenone and l-acetyl-2-thiourea in NMP (N-methyl-2-pyrrolidone) using a microchip reador under EOF conditions [10] (for EOF see [11]) [10] This is claimed to be the first example of a heated organic reaction performed on a glass chip reactor under electroosmotic flow control, whereas only room temperature reactions were made earlier. In a wider scope, the Hantzsch synthesis is a further example to evaluate the potential of microfluidic systems for high-throughput... 

The Nervous Systems Research branch of Novartis Pharma Ltd in Basel, Switzerland, carried out the aldol reaction using a microchip reador under eledroosmotic flow conditions. Aldol reactions are well-established routes for C—C bond formation in organic chemistry. 

SmithKline Beecham Pharmaceuticals in Harlow, UK, carried out Wittig reactions using a microchip reador under eledroosmotic flow conditions. 2-Nitrobenzyltri-phenylphosphonium bromide was readed with methyl 4-formylbenzoate and four other aldehydes, 3-benzyloxybenzaldehyde, 2-naphthaldehyde, 5-nitrothiophene-2-carboxaldehyde and 3-dimethylamino-4-propoxybenzaldehyde [16,17]. 

To prevent the formation of byproducts like L-malic add and D-alanine, the cells undergo a pH-treatment to inactive fumarase and alanine racemase. Several reactor conformations have been investigated, but a two reactor system was found to be die most effective. The flow sheet of mis two reador system is given in Figure A8.15. In the first reactor L-aspartic add is formed, which reacts in the second reador to L-alanine. 

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