Flow rate narrow-bore packed-column HPLC

The design of hydraulic systems for narrow-bore packed column HPLC Is particularly challenging because of the low flow rate used In narrow-bore packed columns. The potential performance of narrow-bore packed columns Is greatly reduced by the constraint of operable constant low flow rates and the operable pressure limit. [Pg.100]

The driving forces for the rapid development and growth In mlcrobore column HPLC are (1) savings In solvent consumption a total saving of up to 99.9% can be achieved when narrow-bore microparticle packed columns or open—tubular micro-capillary columns are used (2) the high separation power using long column and small particles (e.g., 3 nm) (3) the compatibility of the column eluent flow rates with a mass spectrometer and flame based detectors and (4) opportunities In new detector development,... [Pg.91]