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Flexible design-planning

Flexible Design—Planning of Supply Chain Networks... [Pg.109]

Here, the flexible design-planning approach presented in Chap. 5 is utilized. This model is suitable to collect all SC nodes information through a single variable, which facilitates the environmental formulation. This way SC nodes characteristics are modeled with a single equation set, since manufacturing nodes and distribution centers are treated in the same manner as well as production and distribution activities. The model s details are in Chap. 5. [Pg.138]

Lainez, J. M., Kopanos, G., Espu na. A., Puigjaner, L. (2009a). Flexible design-planning of supply chain nstv/orks. AIChE Journal, 55, 1736-1753. [Pg.298]

A recent European regulatory document (CHMP (2006) Reflection Paper on Methodological Issues in Confirmatory Clinical Trials with Flexible Design and Analysis Plan ) has given more thought to what is acceptable and what is not, in terms of flexible design. Several common themes are seen to run through this paper ... [Pg.225]

CHMP (2006) Reflection Paper on Methodological Issues in Confirmatory Clinical Trials with Flexible Design and Analysis Plan... [Pg.248]

Undertaking interim analyses for either efficacy or futility or both, together with sample size re-evaluation already provides a range of flexibility in the design and planned correctly these approaches may cover many situations of practical interest. What more could be done Phillips and Keene (2006) list a range of potential adaptations including the following ... [Pg.225]

Fig. 16.6. Objectives of the first round library. The main goal is to explore the protein pocket probed by the right-hand side of Cpd-1 to improve kinase selectivity and further build SAR knowledge. The single aryl-aryl bond was replaced by three bonds containing an amide group with more flexibility. A registered combinatorial synthesis protocol (LJ0194) was used for this library and a 2x44 plate format was planned before the design of the library. Fig. 16.6. Objectives of the first round library. The main goal is to explore the protein pocket probed by the right-hand side of Cpd-1 to improve kinase selectivity and further build SAR knowledge. The single aryl-aryl bond was replaced by three bonds containing an amide group with more flexibility. A registered combinatorial synthesis protocol (LJ0194) was used for this library and a 2x44 plate format was planned before the design of the library.
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See also in sourсe #XX -- [ Pg.109 , Pg.138 ]



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