Hyponatremia flecainide

Electrolyte balance Hyponatremia of 127 mmol/1 in a 67-year-old woman with normal renal function who was taking flecainide 100 mg bd was attributed to the flecainide [59" ]. The authors proposed that flecainide had inhibited renal and intestinal epithehal sodium channels, preventing... 

Ahmed M, Sra J, Akhtar M, Mortada ME. A case of flecainide-induced hyponatremia. J Cardiovasc Electrophysiol 2009 20(10) 1170-2. 

Electrolyte balance Severe flecainide-in-duced hyponatremia has been described [64 ]. 

In this case, hyponatremia was precipitated by flecainide and recovered after drug withdrawal. The authors postulated that the mechanism was direct inhibition of renal and intestinal epithelial sodium channels, leading to reduced sodium reabsorption. 

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