Flavoproteins, prototypes

Table I. Prototypes of Flavoproteins and Number of Redox Equivalents Transferred in a Single Input and Output Step0...

Redox-Equivalents Input/Output Flavoprotein Function Prototype... 

Kim JJ, Shen AL, XiaC (2012) Structure and catalytic mechanism of NADPH-cytochrome P450 oxidoreductase a prototype of the diflavin oxidoreductase family of enzymes. In Hille R, Miller S, Palfey B (eds) Handbook of flavoproteins, vol 2. de Gruyter, Berlin, pp 73-101... 

Dithiol-disulphide redox roles in primitive systems would have favoured the development of dicysteinyl peptides, restraining two thiols in close proximity. Thioredoxin type molecules would have evolved from these small prototype dithiol peptides. Similar centres would also have developed as parts of more complex enzymes. The binding of a flavin coenzyme near a dithiol centre could eventually have produced the combined disulphide-flavoprotein centre with its special redox properties. 

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