Flavonoids plasma half life

For most flavonoids, the maximum concentration in human plasma occurs 1-6 hours after ingestion with an elimination half-life (t1/2) from 1 to 28 hours.15-21 Therefore, flavonoids can accumulate in the circulation and in tissues with frequently repeated intakes. Plasma quercetin in free-living subjects, measured after overnight fast, is typically 50-80 nmol/L, though smaller values are observed following a low-flavonoid diet.15 Conversely, supplementation with 500 mg/d rutin for 6 weeks increased plasma quercetin to 165 nmol/L22 and to 0.63 and 1.5 prnol/L following supplementation with 80 mg and >1 g quercetin equivalents daily for 7 and 28 days, respectively.23-24... 

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