FITC-sinistrin

Recently, the measnrement of FITC-sinistrin using the transcutaneous device (optical GFR) was directly compared with simultaneous GFR measurements obtained from gadolinium-based contrast agent filtration in the MRI (MRI-GFR ZoUner et al., 2013). While discrepancies between the two detection methods were observed, the study demonstrated that MRI-GFR, similarly to optical GFR, allowed for visualization of the filtration function in healthy and unilateral nephrectomy rats (Zollner et al., 2013). 

Schock-Kusch D, Sadick M, Henninger N, Kraenzlin B, Claus G, Kloetzer H-M, WeiB C, Pill J, and N Gretz (2009). Transcutaneous measurement of glomerular filtration rate using FITC-sinistrin in rats. Nephrology, Dialysis, Transplantation 24 2997-3001. 

Schock-Kusch D, Xie Q, Shulhevich Y, Hesser Y, Stsepankou D, Sadick M, Koenig S, Hoecklin F, PiU J, and N Gretz (2011). Transcutaneous assessment of renal function in conscious rats with a device for measuring FITC-sinistrin disappearance curves. Kidney International 79 1254—1258. 

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