Fischer projections racemic mixtures

The separation of a racemic mixture into its enantiomeric components is termed resolution The first resolution that of tartaric acid was carried out by Louis Pasteur m 1848 Tartaric acid IS a byproduct of wine making and is almost always found as its dextrorotatory 2R 3R stereoisomer shown here m a perspective drawing and m a Fischer projection... 

Biological Discrimination of Enantiomers 189 5-6 Racemic Mixtures 191 5-7 Enantiomeric Excess and Optical Purity 192 5-8 Chirality of Conformationally Mobile Systems 193 5-9 Chiral Compounds without Asymmetric Atoms 195 5-10 Fischer Projections 197... 

An efficient and large scale resolution of methylphenidate (ritalin hydrochloride)using dibenzoyl-tartaric acid has been described (61). Ritalin is marketed for the treatment of children with attention deficient disorder (ADHD). Methylphenidate has two chiral centers and originally was marketed as a mixture of two racemates, 20% OL-threo (29, 30) and 80%DL-erythro (31, 32) (see Fig. 18.12 for the structures of all four isomers). As introduced previously, the erythro-isomer is defined as the case when the main chain of a molecule (drawn vertically in a Fischer projection)has identical or similar substituents at two adjacent non-identical chiral centers on the same side of the chain, whereas the threo isomer has... 

---

See also in sourсe #XX -- [ ]

---