Fischer, Edmund

The Coris found that the interconversion of phosphor-ylases a and b is catalyzed by another enzyme, and subsequent work by Earl Sutherland showed that this process is under hormonal control. In muscle, conversion of phosphorylase b to a is stimulated by epinephrine in liver, it is stimulated by both epinephrine and the pancreatic hormone glucagon. The structural basis for the difference between the two forms of phosphorylase remained unknown until the late 1950s, when Edwin Krebs and Edmund Fischer showed that phosphorylase a has a phosphate on serine 14. This phosphate is absent in the b form of the enzyme. Krebs and Fischer also showed that the kinase that catalyzes the addition of the phosphate is itself regulated by a phosphorylation catalyzed by another enzyme, the cAMP-dependent protein kinase ... 

M. E. Felver 18 Edmund H. Fischer 4 J. E. Fothergill 13 William A. Frazier 12 Rene Frenkel 9... 

Edmund H. Fischer, Ludwig M. G. Heilmeyer, Jr., and Richard H. Haschke... 

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