Fimbriae virulence

An important virulence factor of bacteria is their ability to adhere to urinary epithelial cells by fimbriae, resulting in colonization of the urinary tract, bladder infections, and pyelonephritis. Other virulence factors include hemolysin, a cytotoxic protein produced by bacteria that lyses a wide range of cells... 

The PE fimbriae, encoded by the pefBACD operon contained on the virulence plasmid pSLT, has been found in only four Salmonella serotypes, S. typhimurium, S. choleraesuis, S. paratyphi, and S. enteritidis (Baumler etal, 1997). The PE fimbria has been demonstrated to mediate adherence to the... 

Bouwman, C. W., Kohli, M., Killoran, A., Touchie, G. A., Kadner, R. J., and Martin, N. F. (2003). Characterization of SrgA, a Salmonella enterica serovar Tjrphimurium virulence plasmid-encoded paralogue of the disulfide oxidoreductase DsbA, essential for biogenesis of plasmid-encoded fimbriae. /. Bacteriol. 185, 991-1000. 

Nor berg et al. [149] have also synthesised the disaccharides gal-a-(l —> 2)-L-rha and gal-oe-(l - 2)-D-man as analogs of methyl urobioside to investigate the binding by the fimbriae of virulent E. coli strains. 

---