Fibrinolytic Therapy Trial Collaborative Group

As we have noted previously (30), The Fibrinolytic Therapy Trialists Collaborative Group summarized results from early clinical trials as follows 35 lives could be saved per 1000 patients with STEMI when... 

Fibrinolytic Therapy TriaUsts (FTT) Collaborative Group. Indications for fibrinolytic therapy in suspected acute myocardial infarction collaborative overview of early mortality and major morbidity results from aU randomised trials of more than 1000 patients. Lancet 1994 343(8893) 311-22. 

In 1994, the benefit of fibrinolytic therapy in the treatment of the elderly was brought into question by the Fibrinolytic Therapy Trialists (FTT) Collaborative Group (3). This meta-analysis included nine fibrinolytic trials incorporating over 58,600 patients. Of these patients, 17,000 were 65-74 years of age and 5754 were >75 years of age. This analysis revealed that the benefit of fibrinolytic therapy diminished with advancing age relative risk reduction (RRR) of death associated with fibrinolytic therapy was 22% in patients <55 years of age, 19% in patients 55-64 years of age, 16% in patients 65-74 years of age and only 4% in patients >75 years of age. However, while the relative effectiveness of fibrinolytic therapy diminished with advancing age, the 4% RRR translated into a 1% ARR, or NNT = 100, still a clinically important difference and similar to the 1.2% ARR in patients <55 years of age. Therefore, even small relative reductions in risk can be important when applied to groups with increased risk. 

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See also in sourсe #XX -- [ ]

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