Fibrillin microfibrils folding

Fibrillin-rich microfibrils have endowed tissues with elasticity throughout multicellular evolution. X-ray studies and mechanical testing of microfibril bundles showed that bound calcium influences load deformation, but is not necessary for high extensibility and elasticity (Eriksen et al, 2001 Wess et al, 1997, 1998a,b). Thus, tissue microfibril elasticity is modified by, but not dependent on, calcium-induced beaded periodic changes. This is consistent with the molecular folding model. 

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