Ferriphos ligand

The straightforward synthesis of the diamino FERRIPHOS ligand offers a convenient access to this class of ferrocenyl ligands1321 and makes this ligand well suited for applications in asymmetric hydrogenation. 

Table 12.5 Asymmetric hydrogenation of a-acetamidoacrylates using the (S)-(R)-diamino FERRIPHOS ligand.

Furthermore FERRIPHOS ligands bearing alkyl groups instead of dimethy-lamino substituents proved to be excellent ligands in the asymmetric hydrogenation of a-acetamidoacrylic acids[34] and acetoxy acrylic esters[35l Their air stability and the easy modification of their structure make the FERRIPHOS ligands particularly useful tools for asymmetric catalysis. 

Ligand Cj-Ferriphos Ligand PPF-P Buj Ligand Cg-Ferriphos Ligand C2-Ferriphos... 

A C2-symmetric bisphosphane FerroPhos has been developed by Kang and is found to be efficient for the Rh-catalyzed hydrogenation of a-dehydroamino acid derivatives.86,863 Knochel has independently reported a class of FERRIPHOS (MandyPhos) with similar structural features. All these ligands have provided excellent... 

Developments after these Ugi derivatives have taken a number of pathways. The MandyPhos family of ligands (32) have been used to reduce enamides to 01-amino acids as well as an enol acetate to produce an a-hydroxy ester [134—140]. The substituents R and R1 can be used for the fine-tuning of a specific substrate. Many of the family have R1 as a secondary amine, relating the family back to PPFA. For confusion, MandyPhos has also been called FerriPhos, while the derivative 32 (R = Rx = Et) is known as FerroPhos. 

SYNTHESIS AND APPLICATION OF DIAMINO FERRIPHOS AS A LIGAND FOR ENANTIOSELECTIYE Rh-CATALYSED PREPARATION OF CHIRAL a-AMINO ACIDS... 

ASYMMETRIC HYDROGENATION OF METHYL-(Z)-3-PHENYL-2-METHYL-CARBOXAMIDO-2-PROPENOATE USING (S)-(R)-DIAMINO FERRIPHOS AS THE CHIRAL LIGAND... 

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