Ferredoxins interconversions

In particular, the study of SRB ferredoxins enables us to survey the different properties of simple iron-sulfur proteins, including electron transfer, flexibility in coordination chemistry, and ability to undergo cluster interconversions. Most of the observations can be extrapolated to more complex situations. 

An abbreviation for Ifigh-potential iron-sulfur protein, which is now regarded as a ferredoxin. In its role as a bacterial electron transfer component, this [4Fe-4S] cluster protein can undergo interconversion to the [4Fe-4S] and [4Fe-4S] states. 

Multi-thiolate iron-protein clusters are also found in the ferredoxin family of electron transport proteins. In particular, the interconversion between ferredoxin clusters... 

The redox interconversions of Fe4S4 sites illustrating the three-state model. The states are found in (A) oxidized HiPIP (B) reduced HiPIP and oxidized ferredoxin (C) reduced ferredoxin. 

The smaller proteins, i.e. ferredoxins, which show [173] interconvertibility between [3Fe-4S] and [4Fe-4S] core types are valuable since representative 3-D structures are available and there are extensive sequence data. It thus becomes possible to investigate the features that determine which structure is more stable and how rapidly they may interconvert. In most cases there is a clear preference for one core type over the other, and interconversion requires prolonged treatment... 

---