Fermentor CSTF

Cell Growth in Batch Fermentors and Continuous Stirred-Tank Fermentors (CSTF) S3... 

There are two different ways of operating continuous stirred-tank fermentors (CSTFs), namely chemostat and turbidostal. In the chemostat, the flow rate of the... 

As mentioned in Section 7.2.1, a well-mixed stirred-tank reactor, when used continuously, is termed a continuous stirred-tank reactor (CSTR). Similarly, a well-mixed stirred-tank fermentor used continuously is termed a continuous stirred-tank fermentor (CSTF). If cell death is neglected, the cell balance for a CSTF is given as... 

There are two different ways of operating a continuous stirred-tank fermentor, namely chemostat and turbidostat. In the chemostat, the flow rate of the feed medium and the liquid volume in the fermentor are kept constant. The rate of cell growth will then adjusts itself to the substrate concentration, which depends on the feed rate and substrate consumption by the growing cells. In the turbidostat the liquid volume in the fermentor and the liquid turbidity, which varies with the cell concentration, are kept constant by adjusting the liquid flow rate. Whereas, turbidostat operation requires a device to monitor the cell concentration (e.g., an optical sensor) and a control system for the flow rate, chemostat is much simpler to operate and hence is far more commonly used for continuous fermentation. The characteristics of the continuous stirred-tank fermentor (CSTF), when operated as a chemostat, is discussed in Chapter 12. 

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