Fentanyl Fluconazole

Some patients may experience prolonged and increased alfentanil effects if they are given fluconazole or voriconazole. In vitro data surest itraconazole and ketoconazole may interact similarly. Intravenous fentanyl does not appear to interact with itraconazole in healthy subjects, but one case of possible opioid toxicity from transdermal fentanyl has been reported. 

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