Feasible Label Routing

NIOSH REL (Methylene Chloride) Reduce to lowest feasible level DOT CLASSIFICATION 6.1 Label KEEP AWAY FROM FOOD SAFETY PROFILE Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by intravenous route. Moderately toxic by ingestion, subcutaneous, and intraperitoneal routes. Mildly toxic by inhalation. Human systemic effects by ingestion and inhalation paresthesia, somnolence, altered sleep time,... 

The commercial availabUity of pHJfolic add at high-spedfic activity has made feasible many studies of folate kinetics. The studies involving bolus dose administration of the labeled folate consistently have shown a biphasic curve for disappearance of folate by urinary and fecal routes. Representative of this approach is the well-designed study by Tamura and Halsted (1983) of folate metabolism in monkeys. Following a bolus dose of pHJfolic add, the isotope was excreted by fecal and urinary routes. The extent of... 

Devising a synthetic route incorporating isotope labels into small organic molecules must naturally take into account the technical feasibility of introducing the isotopic labels into the final compound from commercially available... 

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