Fatty liver dystrophy

G.A. Langner, E.h. Birkenmeier, O. Ben-Zeev, M.C. Schotz, H.O. Sweet, M.T. Davisson, and J.L Gordon, The fatty liver dystrophy (fid) mutation. A new mutant mouse with a developmental abnormality in triglyceride metabolism and associated tissue-specific defects in lipoprotein lipase and hepatic lipase activities, J. Biol. Chem., 1989, 264, 7994-8003. 

Morphologically expressed protein and fatty dystrophy of the liver and kidneys, and a depletion of glycogen in the liver, are all evidence of the... 

Inositols, ie, hexahydrobenzenehexols, are sugars that have received increasing study and are useful in the treatment of a wide variety of human disorders, including vascular disease, cancer, cirrhosis of the liver, frostbite, and muscular dystrophy (269). Myoinositol esters prepared by reaction with lower fatty acid anhydrides are useful as liver medicines and nonionic surfactants the aluminum and ammonium salts of inositol hexasulfate are useful anticancer agents (270). Tetraaryloxybenzoquinones are intermediates in the preparation of dioxazine dyes (266,271). The synthesis of hexakis(aryloxy)benzenes has also been published (272). 

Liver size The liver may have normal size or it can be enlarged due to hyperaemia or massive fatty infiltration. A rapid shrinking of the liver to less than 1000 ml in volume ( dystrophy , acute atrophy ) - requiring sonographic or CT monitoring at the bedside - is deemed to be a poor prognostic sign. 

Witting- and Horwitt, 1962). This was done by comparing diets which contain saturated fats and a minimum of added linoleic acid and diets adjusted to provide different larger amounts of unsaturated fatty acids (Table I). Peroxidizability of tissues was estimated by arbitrarily giving a value of 1, 2, 4, 8, and 8 to the relative peroxidizability of diene, triene, tetraene, pentaene, and hexaene, respectively. It had previously been noted that when little or no tocopherol was present in such diets, the rate of appearance of dystrophy was slowest on the coconut oil diet and most rapid on the cod liver oil diet (Century and Horwitt, 1960 Century et al., 1961). If no tocopherol was provided to diets equal in unsaturation in terms of iodine value, as supplied by monoene, diene, triene, and polyene in syn-... 

Kirov, M.. Burkova, T., Kapurdov, V., Spasovski, M. 1988a. Rose oil. Lipotropic effect in modelled fatty dystrophy of the liver. Afe[Pg.425]

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