Fatty acid acyl CoA, derivatives

This enzyme, which has been purified some 200-fold, also catalyzes the synthesis of ceramide from sphingosine and free fatty acid. Acyl CoA derivatives are active only after hydrolysis by thiolase to release free fatty acid which is then available to condense with sphingosine. Attempts to dissociate these enzymic processes from one another have been unsuccessful. The preparation showed hydrolytic activity (ceramidase) toward A-palmitoyl, oleoyl, and stearoyl sphingosine, as well as with. V-palmitoyl dihydrosphingosine. Cerefarosides, sphingomyelin, and iV-acetyl sphingosine were not cleaved. 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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