Fasciospongia

Epoxy-latrunculin A (478) and latrunculin M (479) were isolated from L. magnified. The structures were established by chemical and spectral methods [408]. Latrunculin A (205) was isolated from Fasciospongia rimosa collected in Okinawan waters and the absolute configuration was determined by X-ray analysis [409]. F. rimosa also contained the cytotoxic latrunculin S (480) and the structure was elucidated by NMR spectroscopy and chemical correlation with known congeners [410]. 

Mamanuthaquinone (1) was identified in 1991 as a secondary metabolite of a marine sponge.1 Its name is derived from the site of the organism s discovery, the island Mamanutha near the Fiji Islands. The purple moss-like sponge is classified as Fasciospongia sp. 

Idiadione (56) was synthesized from citronellal, establishing the stere-ogenic center as S [31], Cytotoxic sesterterpenoid cacospongionolide D (57) was isolated from Fasciospongia cavernosa from the Bay of Naples [32]. Thorectolide monoacetate (58), obtained from a New Caledonian marine sponge identified as a Hyrtios species [33], in contrast possessed antiinflammatory properties. The bicyclic lactone astakolactin (59) was obtained... 

However, a more potent natural product is (-)-zampanolide (-)-2 which was isolated from the marine sponge Fasciospongia rimosa in 1996 by Higa et al. (-)-2 exhibits significant activity against a variety of tumor cell lines and can be readily obtained from (-)-dacty-lolide (-)- via a reaction sequence reported by Hoye and coworkers. " ... 

Cavemosolide (151), isolated from the Tyrrhenian sponge Fasciospongia cavernosa, is the 24 epimer of petrosaspongiolide M (145)... 

Zhao ZB, Sun JZ, Mao SC, Guo YW. Fasciospyridine, a novel sesquiterpene pyridine alkaloid from Guangxi sponge Fasciospongia sp. J Asian Nat Prod Res 2013 15 (2) 198-202. 

Constit. of Fasciospongia cavernosa. Oil. Poss. artifact as the biol. sample was stored in MeOH. 

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