Family studies obsessive-compulsive disorder

Mundo, E., Richter, M. A., Zai, G., et al. (2002) 5HTlDbeta Receptor gene implicated in the pathogenesis of obsessive-compulsive disorder further evidence from a family-based association study. Mol. Psychiatry. 7, 805-809. 

There are also very few controlled family studies of obsessive-compulsive disorder. Two of the three studies (Pauls et al. 1995) reported familial relative risks of 3-4, whereas a third study (Black et al. 1992) found no evidence for familial aggregation. Nestadt et al. (2000) found that both an early age of onset and obsessions, but not compulsion were associated with greater familiality. Twin studies have yielded weak evidence for heritability of obsessive-compulsive disorder (Bellodi et al. 1992 Carey and Gottesman 1981 Lenane et al. 1990). 

Black DW, Noyes R Jr, Goldstein RB, Blum N (1992) A family study of obsessive-compulsive disorder. Arch Gen Psychiatry 49 362-368... 

Hanna, G.L. (2000) Clinical and family-genetic studies of childhood ohsesslve-compulslve disorder. In Goodman, W.K., Rudorfer, M.V., and Maser, J.D., eds. Obsessive-Compulsive Disorder Contemporary Issues in Treatment. Mahwah, NJ Lawrence Erl-haum Associates, pp. 87-103. 

Karayiorgou, M., Sobin, C., Blundell, M.L., Galke, B.L., Malinova, L., Goldberg, P., Ott, J., and Gogos, J.A. (1999) Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder. Biol Psychiatry 45 1178-1189. 

Nestadt, G., Samuels, J., Riddle, M., Bienvenu, O.J., Liang, K.Y., LaBuda, M., Walkup, J., Grados, M., and Hoehn-Saric, R. (2000) A family study of obsessive-compulsive disorder. Arch Gen Psychiatry 57 358-363. 

Reddy, PS., Reddy, Y.C., Srinath, S., Khanna, S., Sheshadri, S.P., and Girimaji, S.R. (2001) A family study of juvenile obsessive-compulsive disorder. Can Psychiatry 46 346-351. 

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