Factors That Affect Gas Dispersion

Gas dispersion in bioreactors is a process that has a complex dependence on various factors. Firstly, the gas flow rate has an important bearing on the hydrodynamics of two-/three-phase reactors. A measure of aeration rate that has been conventionally used to represent the air flow rate in stirred bioreactors is vvm. Chapman et al. (1983b) have shown that the use of vvm eliminates the scale-up effect since vvm is the reciprocal of the residence time of the gas phase Schluter and 

STIRRED TANK REACTORS EOR CELL CULTURE TECHNOLOGY 

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