Factors Influencing In Vivo Drug Retention

FACTORS INFLUENCING IN VIVO DRUG RETENTION Anion or Polyanion Used as Trapping Agent 

Some questions have also been raised about the activity of liposomal agents prepared using polyanions because highly stable liposomes loaded with 

The size of the liposome determines the entrapped volume (47) and thus limits the amount of drug that can be entrapped in a single liposome. 

This chapter reviews the methodology and characterization of novel intraliposomal drug stabilization strategies. In order to achieve highly stable 

Drummond DC, Meyer O, Hong K, et al. Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors. Pharmacol Rev 1999 51(4) 691. 

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