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Intraliposomal drug stabilization

This chapter reviews the methodology and characterization of novel intraliposomal drug stabilization strategies. In order to achieve highly stable... [Pg.164]

Intraliposomal Trapping Agents for Improving In Vivo Liposomal Drug Formulation Stability... [Pg.149]

Figure 7 The stability of liposomal VCR in liposomes prepared using different triethylammonium ion gradients. VCR can be deformylated under acidic conditions, similar to those found in the intraliposomal lumen of remote-loaded liposomes. (A) The deformylated product is inactive compared to the parent drug. (B) HPLC chromatograms show peaks for both VCR (rt = 9.5 minutes) and deformylated VCR (rt= 11.1 minutes) for liposomes prepared with either sulfate or citrate as the intraliposomal trapping agent and stored for three months at 4°C to 6°C. Abbreviation VCR, vincristine. Figure 7 The stability of liposomal VCR in liposomes prepared using different triethylammonium ion gradients. VCR can be deformylated under acidic conditions, similar to those found in the intraliposomal lumen of remote-loaded liposomes. (A) The deformylated product is inactive compared to the parent drug. (B) HPLC chromatograms show peaks for both VCR (rt = 9.5 minutes) and deformylated VCR (rt= 11.1 minutes) for liposomes prepared with either sulfate or citrate as the intraliposomal trapping agent and stored for three months at 4°C to 6°C. Abbreviation VCR, vincristine.
See other pages where Intraliposomal drug stabilization is mentioned: [Pg.152]    [Pg.152]    [Pg.150]    [Pg.162]    [Pg.459]    [Pg.2]    [Pg.158]    [Pg.161]   


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Drug stability

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